The world's best player Lionel Messi lit up the opening night of the Champions League for Barcelona although holders Inter Milan and Manchester United endured less than sparkling starts on Tuesday.
Holders Bayern Munich recovered from the shock of a stunning Patrice Evra goal to score three times in quick succession to beat Manchester United 3-1 and reach the Champions League semi-finals on Wednesday.
Twenty-three-times Cup winners Athletic Bilbao were dumped out in sensational circumstances by tiny island side SD Formentera, who sneaked a 1-0 win at San Mames with a header by Alvaro Muniz deep in stoppage-time to reach the last 16 for the first time with a 2-1 aggregate victory.
The UEFA Champions League kicks off this week with powerhouses such as favourites Barcelona and holders Inter Milan yet to hit their stride, leaving the door open for nasty surprises in games they would ordinarily win.
Lionel Messi's brilliance sent holders Barcelona through to the Champions League quarter-finals with a 4-0 dismantling of VfB Stuttgart on Wednesday.
Cristian Tello hit a hat-trick as Barcelona came from behind to win 4-1 in their King's Cup quarter-final first leg at Levante on Wednesday and Lionel Messi celebrated his 400th appearance for the Catalan side.
Lionel Messi's injury is a painful blow for Barcelona but is also a motivation for the rest of the squad, midfielder Ivan Rakitic said before the holders host Bayer Leverkusen in Champions League Group E on Tuesday.
Jose Mourinho and his Inter Milan players managed to stifle Champions League holders Barcelona last week at the San Siro but repeating the feat at the Nou Camp on Wednesday is a different proposition altogether.
Barcelona took a big step towards the Champions League semi-finals.
Cristiano Ronaldo scored a sensational goal and was then sent off for a combination of his provocative celebration and for diving as Real Madrid beat Barcelona 3-1 in an explosive Spanish Super Cup first leg on Sunday.
Atletico Madrid secured a berth in the Champions League group stage for next season and Deportivo La Coruna narrowly escaped relegation when they came from two goals down to draw 2-2 at champions Barcelona on the final day in La Liga on Saturday.
Barcelona earned a 1-1 draw with holders Sevilla in the first leg of the King's Cup last-16.
As Barca prepare for a trip to Madrid to play Rayo Vallecano on Saturday, they are still reeling from Tuesday's 3-2 Champions League reverse at Paris St Germain, when their defence was badly exposed by the Ligue 1 title holders.
Barcelona must appreciate matching the club's record of nine wins and a draw in their first 10 games of a Liga campaign, especially after Real Madrid's defeat at Girona, coach Ernesto Valverde told a news conference on Monday.
Pep Guardiola will return to the Nou Camp in the Champions League group stage after his new club Manchester City were drawn against his former Barcelona team on Thursday. The two sides were drawn in Group C alongside Borussia Moenchengladbach and former European champions Celtic in one of the toughest of the eight sections. Spanish coach Guardiola, who won the Champions League twice with Barca, faced the Catalans when he was in charge of Bayern Munich two seasons ago and suffered a 5-3 defeat in the semi-finals.
Images from Tuesday's action in the UEFA Champions League.
A round-up of Wednesday's action in the UEFA Champions League.
Real Madrid kept alive their hopes of overhauling La Liga leaders Barcelona when a James Rodriguez stunner set them on their way to a serene 3-0 home victory over struggling Almeria on Wednesday.
Sevilla knocked Barcelona off the top of the Primera Liga after goals from Frederic Kanoute and Adriano Correia earned a 2-0 home win over Osasuna on Sunday.
Real Madrid and Barcelona pulled two points clear in La Liga when Cristiano Ronaldo set a club scoring record in Real's 3-0 stroll against Levante and Neymar hit four as Barca beat Rayo Vallecano 5-2 on Saturday.
Dinamo Zagreb midfielder Arijan Ademi failed a drug test after their Champions League match against Arsenal last month and is under investigation by UEFA, the club said on Wednesday.
Lionel Messi struck a spectacular free kick, scored another goal and set up two more in a 4-1 victory for Barcelona over nine-man city rivals Espanyol in the first leg of their King's Cup last-16 clash on Wednesday.
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
Barcelona's Lionel Messi broke free from Arsenal's shackles to score two late goals and put the Champions League holders on the brink of the quarter-finals with a clinical 2-0 victory at the Emirates Stadium on Tuesday.
La Liga leaders Real Madrid dropped points at home for only the second time this season.
Images from action in the Spanish Super Cup and English Premier League
Real Madrid coach Carlo Ancelotti fended off questions about his future after the Champions League holders were dumped out in the semi-finals by Juventus 3-2 on aggregate on Wednesday.
Barcelona's Lionel Messi and Luis Suarez secured victory over nine-man Atletico Madrid in La Liga's top of the table clash, while Juventus won a 12th straight Serie A game to stay hot on the heels of leaders Napoli.
News of all that transpired on and off the football field.
Bayern Munich's surprise 3-1 Champions League loss to Porto was the price the five-time European champions paid for a string of injuries and a tired squad.
The Real Madrid forward apologises after Real Madrid dumped out of King's Cup by Atletico Madrid.
Real Madrid forward Cristiano Ronaldo collected a record fourth Golden Shoe award as Europe's top scorer on Tuesday for his 48-goal haul in La Liga last season.
A summary of Wednesday's matches in the UEFA Champions League.
Real Madrid can bury Atletico's hopes of winning La Liga with a third straight victory against their city neighbours on Sunday that would leave the capital's second club trailing by six points.
Juventus shattered Real Madrid's dream of a record-extending 11th European crown when Alvaro Morata scored against his former club to secure a 1-1 Champions League draw with the holders on Wednesday and send Juve into the final 3-2 on aggregate.
The King's Cup descended into farce on Thursday when Racing Santander's players, protesting over unpaid wages, refused to challenge for the ball after their quarter-final second leg at home to Real Sociedad kicked off.
Real Madrid moved four points clear of Barcelona at the top of La Liga with Cristiano Ronaldo scoring either side of a Gareth Bale strike in a 3-0 win at Getafe on Sunday.
News of all that's transpired on and off the football field